nafld prevalence in a young cadaveric organ donor population

نویسندگان

ali jafarian hepatobiliary and liver transplantation division, department of general surgery, imam-khomeini hospital, tehran university of medical sciences (tums), tehran, ir iran; corresponding author: ali jafarian, hepatobiliary and liver transplantation division, department of general surgery, imam-khomeini hospital, tehran university of medical sciences (tums), tehran, ir iran. tel/fax: +98-2166581657, e-mail:

amirpasha ebrahimi hepatobiliary and liver transplantation division, department of general surgery, imam-khomeini hospital, tehran university of medical sciences (tums), tehran, ir iran

farid azmoudeh ardalan department of pathology, imam-khomeini hospital, tehran university of medical sciences (tums), tehran, ir iran

habibollah dashti hepatobiliary and liver transplantation division, department of general surgery, imam-khomeini hospital, tehran university of medical sciences (tums), tehran, ir iran

چکیده

conclusions our comprehensive literature review showed that our study was the first investigation in iran and the region, which determined the prevalence of nafld based on tissue diagnosis. we believe that the prevalence of nafld/nash in our donors can represent the overall prevalence in this age group in iran. results among 116 cases, two were diagnosed as probable nash. there was a significant association between nafld and male gender (p = 0.04). moreover, we found a higher steatosis level in male gender. there was a significant association between nafld and bmi (p = 0.05). those with bmi more than 27 had severe steatosis. materials and methods all eligible brain dead liver transplant donors were enrolled in the survey from march 21, 2011 to march 21, 2013 in imam-khomeini hospital complex. eligible participants were donors aged 20 to 60 years without any obvious history of liver disease. liver needle biopsy was performed at the end of the transplant operation; time zero biopsy. we calculated the prevalence of nafld among brain-dead donors. moreover, the frequency of nash was calculated based on the nas (nafld activity score). objectives in this study, we determined the prevalence of nalfd in livers of brain-dead donors in imam-khomeini hospital complex, tehran, iran. we assumed that the calculated prevalence would represent nafld prevalence in iranian population in the age range of 20-60 years. background liver transplantation is a critical survival point for patients with end stage liver diseases. it can dramatically increase patients’ survival if the donor liver is intact. one aspect of liver health is absence of steatosis. nonalcoholic steato hepatitis (nash) and nonalcoholic fatty liver disease (nafld) are increasing among young adults and patients living with chronic liver diseases.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

NAFLD Prevalence in a Young Cadaveric Organ Donor Population

BACKGROUND Liver transplantation is a critical survival point for patients with end stage liver diseases. It can dramatically increase patients' survival if the donor liver is intact. One aspect of liver health is absence of steatosis. Nonalcoholic Steato Hepatitis (NASH) and Nonalcoholic Fatty Liver Disease (NAFLD) are increasing among young adults and patients living with chronic liver diseas...

متن کامل

Donor sepsis is not a contraindication to cadaveric organ donation.

Systemic donor infection is regarded as being an absolute contraindication to cadaveric organ donation for transplantation. This is largely due to fear of transmitting pathogenic organisms to the immunosuppressed recipient. However, due to the current shortage of organs available for transplantation, clinicians are faced with the option of using organs from 'non-ideal' donors, such as those pat...

متن کامل

Variation in cadaveric organ donor rates in the UK.

BACKGROUND Considerable variation exists in the organ donation rate between kidney retrieval areas (KRAs) within the UK. The causes for this are unknown. This study examines whether or not observed variations are correlated with various possible explanatory factors. METHODS A geographical study involving Poisson regression analysis was carried out of all 21 KRAs in the UK in 1999 and 2000, wi...

متن کامل

Prevalence of NAFLD in Healthy and Young Male Individuals

Introduction. Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver disease in adults and the most common cause of liver disease in children (Lavine and Schwimmer 2004). The abnormalities include increased liver fat without inflammation (steatosis) and nonalcoholic steatohepatitis (NASH). NASH may lead to fibrosis, cirrhosis, and ultimately liver failure if it is not treated (...

متن کامل

Commentary on Cadaveric-donor organ recovery at a hospital-independent facility.

BACKGROUND Of the many logistic issues addressed throughout the cadaveric organ donation process, timely access to the operating theater for surgical recovery of organs and tissues can be one of the most problematic. Delay in recovery adds to cost, risks organ viability, and compounds donor family anguish with compromise to donation consent. METHODS From March 1 to November 30, 2001, 25 cadav...

متن کامل

Worldwide Cadaveric Organ Donation Systems

book. Tehran: 2000. p. 23-28.9. Transplant Coordination manual, Manyalich M. TPM educational project. Barcelona (Spain): University of Barcelona; 2001. p. 11-23. 10. Transplant procurement Management, Manyalich M. Organization of Organ Donation and Role of Coordinators. Saudi Journal of Kidney Disease and Transplantation 1999: 175-182. 11. Japan Organ Transplant Network (JOTNW). Available f...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
hepatitis monthly

جلد ۱۴، شماره ۱۰، صفحات ۰-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023